AlphaNet has sponsored more than 60 publications, including peer-reviewed journal articles and posters. Additionally, our medical team has contributed to more than 100 alpha-1 antitrypsin deficiency-related publications.
Peer-reviewed Journal Articles
- Physical and mental health trajectories: A longitudinal SF-36 analysis in Alpha-1 antitrypsin deficiency-associated COPD. Choate R, Holm KE, Sandhaus RA, Mannino DM, Strange C. Respir Med. 2024 Nov-Dec;234:107838. doi: 10.1016/j.rmed.2024.107838. Epub 2024 Oct 14.PMID: 39413887
- Clinical trial attitudes among individuals with Alpha-1 antitrypsin deficiency. Holm KE, Sandhaus RA, Allison S, Strange C. Respir Med. 2024 May 23;229:107676. doi: 10.1016/j.rmed.2024.107676..PMID: 38795925
- Long-Term SGRQ Stability in a Cohort of Individuals with Alpha-1 Antitrypsin Deficiency-Associated Lung Disease. Choate R, Holm KE, Sandhaus RA, Mannino DM, Strange C. Int J Chron Obstruct Pulmon Dis. 2024 Apr 10;19:889-900. doi: 10.2147/COPD.S443183. eCollection 2024.PMID: 38617018
- Characteristics associated with SF-36 in alpha-1 antitrypsin deficiency-associated COPD: a cross-sectional analysis. Choate R, Holm KE, Sandhaus RA, Mannino DM, Strange C. BMC Pulm Med. 2024 Mar 18;24(1):138. doi: 10.1186/s12890-024-02953-7.PMID: 38500152
- Prevalence of Cardiovascular Disease and Rate of Major Adverse Cardiovascular Events in Severe Alpha-1 Antitrypsin Deficiency COPD. Ellis P, Bailey E, Choate R, Holm KE, Sandhaus RA, Turner AM, Newnham M. Int J Chron Obstruct Pulmon Dis. 2024 Jan 17;19:149-159. doi: 10.2147/COPD.S419846. eCollection 2024.PMID: 38249829
- Health-related Quality of Life in Alpha-1 Antitrypsin Deficiency-associated Chronic Obstructive Pulmonary Disease. Choate R, Holm KE, Sandhaus RA, Mannino DM, Strange C. Am J Respir Crit Care Med. 2023 Nov 15;208(10):1132-1134. doi: 10.1164/rccm.202304-0697LE.PMID: 37581489
- Augmentation Therapy for Alpha-1 Antitrypsin Deficiency: Patient Experiences With Self-Infusion, Home Providers, and Clinics. Strange C, Allison S, McCathern J, Sandhaus RA, Holm KE. Chronic Obstr Pulm Dis. 2023 Oct 26;10(4):392-399. doi: 10.15326/jcopdf.2023.0430.PMID: 37549313
- Impact of Coronavirus Disease 2019 and Vaccination Attitudes on Alpha-1 Antitrypsin Deficiency. Hay MA, Holm KE, McCathern J, Sandhaus RA, Strange C. Chronic Obstr Pulm Dis. 2023 Oct 26;10(4):335-342. doi: 10.15326/jcopdf.2023.0406.PMID: 37363861
- Quality of Life and Mortality Outcomes for Augmentation Naive and Augmented Patients with Severe Alpha-1 Antitrypsin Deficiency. Ellis PR, Holm KE, Choate R, Mannino DM, Stockley RA, Sandhaus RA, Turner AM. Chronic Obstr Pulm Dis. 2023 Apr 27;10(2):139-147. doi: 10.15326/jcopdf.2022.0339.PMID: 36749925
- Patient-Reported Pulmonary Symptoms, Exacerbations, and Management in a Cohort of Patients With Alpha-1 Antitrypsin Deficiency. Choate R, Sandhaus RA, Holm KE, Mannino DM, Strange C. Chronic Obstr Pulm Dis. 2022 Oct 26;9(4):549-561. doi: 10.15326/jcopdf.2022.0317.PMID: 36103189
- Home-Based Multicomponent Intervention Increases Exercise Activity and Improves Body Mass Index: Results of a 5-Year Randomized Trial Among Individuals with Alpha-1 Antitrypsin Deficiency-Associated Lung Disease. Choate R, Mannino DM, Holm KE, Beiko T, Boyd B, Sandhaus RA. Chronic Obstr Pulm Dis. 2021 Jan;8(1):7-18. doi: 10.15326/jcopdf.8.1.2020.0183.PMID: 33135406
- Alpha 1 Antitrypsin Therapy in Patients with Alpha 1 Antitrypsin Deficiency: Perspectives from a Registry Study and Practical Considerations for Self-Administration During the COVID-19 Pandemic. Herth FJF, Sandhaus RA, Turner AM, Sucena M, Welte T, Greulich T. Int J Chron Obstruct Pulmon Dis. 2021 Nov 1;16:2983-2996. doi: 10.2147/COPD.S325211. eCollection 2021.PMID: 34754184
- Improving the Lives of Patients with Alpha-1 Antitrypsin Deficiency. Sandhaus RA, Strange C, Zanichelli A, Skålvoll K, Koczulla AR, Stockley RA. Int J Chron Obstruct Pulmon Dis. 2020 Dec 10;15:3313-3322. doi: 10.2147/COPD.S276773. eCollection 2020.PMID: 33328731
- Medical costs of Alpha-1 antitrypsin deficiency-associated COPD in the United States. Sieluk J, Slejko JF, Silverman H, Perfetto E, Mullins CD. Orphanet J Rare Dis. 2020 Sep 23;15(1):260. doi: 10.1186/s13023-020-01523-4.PMID: 32967697
- Limitations and Challenges of Conducting Budget Impact Analyses in Rare Diseases: A Case Study of Alpha-1 Antitrypsin Deficiency. Rueda JD, Sieluk J, Sandhaus RA, Mullins CD. Value Health Reg Issues. 2020 Dec;23:70-76. doi: 10.1016/j.vhri.2020.04.003. Epub 2020 Sep 3.PMID: 32892111
- Detection of alpha-1 antitrypsin deficiency: the past, present and future. Brantly M, Campos M, Davis AM, D’Armiento J, Goodman K, Hanna K, O’Day M, Queenan J, Sandhaus R, Stoller J, Strange C, Teckman J, Wanner A. Orphanet J Rare Dis. 2020 Apr 19;15(1):96. doi: 10.1186/s13023-020-01352-5.PMID: 32306990 Review.
- An analysis of the degree of concordance among international guidelines regarding alpha-1 antitrypsin deficiency. Attaway A, Majumdar U, Sandhaus RA, Nowacki AS, Stoller JK. Int J Chron Obstruct Pulmon Dis. 2019 Sep 5;14:2089-2101. doi: 10.2147/COPD.S208591. eCollection 2019.PMID: 31564856
- Comparing Patients with ZZ Versus SZ Alpha-1 Antitrypsin Deficiency: Findings from AlphaNet’s Disease Management Program. Choate R, Mannino DM, Holm KE, Sandhaus RA. Chronic Obstr Pulm Dis. 2018 Nov 30;6(1):29-39. doi: 10.15326/jcopdf.6.1.2018.0134.PMID: 30775422
- Costs of Medical Care Among Augmentation Therapy Users and Non-Users with Alpha-1 Antitrypsin Deficiency in the United States. Sieluk J, Levy J, Sandhaus RA, Silverman H, Holm KE, Mullins CD. Chronic Obstr Pulm Dis. 2018 Nov 8;6(1):6-16. doi: 10.15326/jcopdf.6.1.2017.0187.PMID: 30775420
- Genotype is associated with smoking and other key health behaviors among individuals with alpha-1 antitrypsin deficiency-associated lung disease. Holm KE, Mannino DM, Choate R, Sandhaus RA. Respir Med. 2018 Oct;143:48-55. doi: 10.1016/j.rmed.2018.08.016. Epub 2018 Sep 1.PMID: 30261992
- Benefits Among Patients with Alpha-1 Antitrypsin Deficiency Enrolled in a Disease Management and Prevention Program. Perkins JT, Choate R, Mannino DM, Browning SR, Sandhaus RA. Chronic Obstr Pulm Dis. 2016 Dec 24;4(1):56-64. doi: 10.15326/jcopdf.4.1.2016.0161.PMID: 28848911
- The Diagnosis and Management of Alpha-1 Antitrypsin Deficiency in the Adult. Sandhaus RA, Turino G, Brantly ML, Campos M, Cross CE, Goodman K, Hogarth DK, Knight SL, Stocks JM, Stoller JK, Strange C, Teckman J. Chronic Obstr Pulm Dis. 2016 Jun 6;3(3):668-682. doi: 10.15326/jcopdf.3.3.2015.0182.PMID: 28848891
- Might your respiratory patient have alpha-1 antitrypsin deficiency? Sandhaus RA, Knebel AR. Heart Lung. 2015 Nov-Dec;44(6):463-4. doi: 10.1016/j.hrtlng.2015.07.003. Epub 2015 Aug 8.PMID: 26260071
- Prospective impact of illness uncertainty on outcomes in chronic lung disease. Hoth KF, Wamboldt FS, Strand M, Ford DW, Sandhaus RA, Strange C, Bekelman DB, Holm KE. Health Psychol. 2013 Nov;32(11):1170-4. doi: 10.1037/a0032721. Epub 2013 Jun 17.PMID: 23772888
- The social environment and illness uncertainty in chronic obstructive pulmonary disease. Hoth KF, Wamboldt FS, Ford DW, Sandhaus RA, Strange C, Bekelman DB, Holm KE. Int J Behav Med. 2015 Apr;22(2):223-32. doi: 10.1007/s12529-014-9423-5.PMID: 25008041
- The impact of age on outcomes in chronic obstructive pulmonary disease differs by relationship status. Holm KE, Plaufcan MR, Ford DW, Sandhaus RA, Strand M, Strange C, Wamboldt FS. J Behav Med. 2014 Aug;37(4):654-63. doi: 10.1007/s10865-013-9516-7. Epub 2013 May 4.PMID: 23645147
- The prospective association of perceived criticism with dyspnea in chronic lung disease. Holm KE, Wamboldt FS, Ford DW, Sandhaus RA, Strand M, Strange C, Hoth KF. J Psychosom Res. 2013 May;74(5):450-3. doi: 10.1016/j.jpsychores.2013.02.001. Epub 2013 Feb 28.PMID: 23597335
- Differences in adjustment between individuals with alpha-1 antitrypsin deficiency (AATD)-associated COPD and non-AATD COPD. Holm KE, Borson S, Sandhaus RA, Ford DW, Strange C, Bowler RP, Make BJ, Wamboldt FS. 2013 Apr;10(2):226-34. doi: 10.3109/15412555.2012.719049.PMID:23547634
- Alcohol use predicts ER visits in individuals with alpha-1 antitrypsin deficiency (AATD) associated COPD. Hoth KF, Ford DW, Sandhaus RA, Strange C, Wamboldt FS, Holm KE. COPD. 2012 Aug;9(4):417-25. doi: 10.3109/15412555.2012.684414. Epub 2012 May 31.PMID: 22651849
- Gene therapy meets stem cells.Sandhaus RA. N Engl J Med. 2012 Feb 9;366(6):567-9. doi: 10.1056/NEJMcibr1113400.PMID: 22316453 No abstract available.
- Exacerbations in subjects with alpha-1 antitrypsin deficiency receiving augmentation therapy. Campos MA, Alazemi S, Zhang G, Wanner A, Salathe M, Baier H, Sandhaus RA. Respir Med. 2009 Oct;103(10):1532-9. doi: 10.1016/j.rmed.2009.04.008. Epub 2009 May 21. PMID: 19464158
- Clinical characteristics of subjects with symptoms of alpha1-antitrypsin deficiency older than 60 years. Campos MA, Alazemi S, Zhang G, Salathe M, Wanner A, Sandhaus RA, Baier H. Chest. 2009 Mar;135(3):600-608. doi: 10.1378/chest.08-1129. Epub 2008 Nov 18.PMID: 19017884
- Effects of a disease management program in individuals with alpha-1 antitrypsin deficiency. Campos MA, Alazemi S, Zhang G, Wanner A, Sandhaus RA. COPD. 2009 Feb;6(1):31-40. doi: 10.1080/15412550802607410.PMID: 19229706
- Augmentation therapy in alpha-1 antitrypsin deficiency. Sandhaus RA. COPD. 2009 Jun;6(3):147-8. doi: 10.1080/15412550902976483.PMID: 19811367
- Clinical practice. Alpha1-antitrypsin deficiency. Silverman EK, Sandhaus RA. N Engl J Med. 2009 Jun 25;360(26):2749-57. doi: 10.1056/NEJMcp0900449.PMID: 19553648
- Alpha-1 antitrypsin augmentation therapy for PI*MZ heterozygotes: a cautionary note. Sandhaus RA, Turino G, Stocks J, Strange C, Trapnell BC, Silverman EK, Everett SE, Stoller JK; Medical and Scientific Advisory Committee of the Alpha-1 Foundation. Chest. 2008 Oct;134(4):831-834. doi: 10.1378/chest.08-0868.PMID: 18842915
- Alpha-1 antitrypsin deficiency: whom to test, whom to treat? Sandhaus RA. Semin Respir Crit Care Med. 2010 Jun;31(3):343-7. doi: 10.1055/s-0030-1254074. Epub 2010 May 21.PMID: 20496303
- Clinical characteristics of subjects with symptoms of alpha1-antitrypsin deficiency older than 60 years. Campos MA, Alazemi S, Zhang G, Salathe M, Wanner A, Sandhaus RA, Baier H. Chest. 2009 Mar;135(3):600-608. doi: 10.1378/chest.08-1129. Epub 2008 Nov 18.PMID: 19017884
- Influenza vaccination in subjects with alpha-1 antitrypsin deficiency. Campos MA, Alazemi S, Zhang G, Sandhaus RA, Wanner A. Chest. 2008 Jan;133(1):49-55. doi: 10.1378/chest.07-1482. Epub 2007 Oct 1.PMID: 17908701
- Alpha-1 antitrypsin deficiency: doing the right thing (or start kissing those frogs). Sandhaus RA. 2006 Aug;3(3):123-4. doi: 10.1080/15412550600859452.PMID:17240613
- Results of a survey of patients with alpha-1 antitrypsin deficiency. Strange C, Stoller JK, Sandhaus RA, Dickson R, Turino G. Respiration. 2006;73(2):185-90. doi: 10.1159/000088061. Epub 2005 Aug 3.PMID: 16141711
- Risk factors for symptom onset in PI*Z alpha-1 antitrypsin deficiency. Mayer AS, Stoller JK, Vedal S, Ruttenber AJ, Strand M, Sandhaus RA, Newman LS. Int J Chron Obstruct Pulmon Dis. 2006;1(4):485-92. doi: 10.2147/copd.2006.1.4.485.PMID: 18044105
- Delay in diagnosis of alpha1-antitrypsin deficiency: a continuing problem. Stoller JK, Sandhaus RA, Turino G, Dickson R, Rodgers K, Strange C. Chest. 2005 Oct;128(4):1989-94. doi: 10.1378/chest.128.4.1989.PMID: 16236846
- Trends in the diagnosis of symptomatic patients with alpha-1 antitrypsin deficiency between 1968 and 2003. Campos MA, Wanner A, Zhang G, Sandhaus RA. Chest. 2005 Sep;128(3):1179-86. doi: 10.1378/chest.128.3.1179.PMID
Posters
- ATS Exercise Poster
- CRC Abstract (2021)
- Alpha-1 Survival Poster
- ATS SF-36 Longitudinal Analysis Poster (2024)
- ATS SF-36 Cross-Sectional Analysis Poster (2024)
- ATS SGRQ Longitudinal Poster (2023)
- ATS SGRQ Cross-Sectional Poster (2023)
- ATS Pulmonary Exacerbations Poster (2022)
- CHEST Pulmonary Symptoms Poster (2021)
- ATS FEV1 Decline Methods Poster (2018)
- ATS BMI in Step Forward Study Poster (2017)
- ATS FEV1 Decline Poster (2017)
- ATS Exercise in Step Forward Study Poster (2017)
- ATS ZZ vs. SZ Poster (2016)
- ATS Survival in ZZ Alphas Poster (2016)
- CHEST Medical Costs of Alpha-1 (Part 2) Poster (2017)
- CHEST Medical Costs of Alpha-1 (Part 1) Poster (2017)